期刊

Advanced  Science

标题

Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes

作者

Xingchen Zhao, Dawei Lu, Qian S. Liu, Yiling Li, Rui Feng, Fang Hao, Guangbo Qu, Qunfang Zhou, Guibin Jiang

摘要
In article 1700296, Qunfang Zhou and co-workers report the hemocompatibility of gold nanorods (GNRs). In contrast to negatively charged GNRs, positively charged GNRs (C-GNRs) induce instant hemolysis. After cellular encapsulation, the GNRs are found to bind with hemoglobin and to induce conformational and functional changes in the protein. This demonstrates that surface modification holds great promise as an approach to improve the biocompatibility of GNRs for clinical use.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/advs.201770058/full