期刊

Chemical Communications

标题

Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells

作者

Ming Cheng, Wei Zhang, Jinghe Yuan, Wangxi Luo, Nan Li, Shixian Lin, Yi Yang, Xiaohong Fang* and Peng R. Chen*

摘要

We achieved single-molecule imaging and tracking of the transforming growth factor type II receptor (TβRII) that was labeled by an organic dye via a genetically encoded unnatural amino acid (UAA) and the copper-free click chemistry. The stoichiometry, mobility and dimerization kinetics of individual TβRII molecules were determined.

原文链接

http://pubs.rsc.org/en/journals/journalissues/cc#!issueid=cc050094&type=current&issnprint=1359-7345