期刊
Science China Materials
标题
Isomerization and rearrangement of boriranes: from chemical rarities to functional materials
作者
Soren K. Mellerup, Suning Wang
摘要
Nanohybrids of carbon dots (CDs)/MnO2-PEG with pH/H2O2-responsivity were synthesized via the redox reaction between the CDs and KMnO4 followed by PEGylation. The as-prepared nanohybrids exhibit synchronously enhanced fluorescence, singlet oxygen generation, and MRI signal in the tumor microenvironment, while changing to “off state” in the normal physiological environment. In vitro and in vivo analyses reveal that the low-toxic CDs/MnO2-PEG nanohybrids can be applied as pH/H2O2-driven nanotheranostics for the concurrent bimodal MR/FL imaging-guided oxygen-elevated photodynamic therapy (PDT) of cancer. This work offers a new nanotheranostic candidate for modulating the unfavorable tumor microenvironment,particularly for the tumor-targeted PDT through precise positioning and oxygen generation
原文链接
http://engine.scichina.com/publisher/scp/journal/SCMs/61/10?slug=browse