期刊
Chemical Communications
标题
Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy
作者
Yiqiao Tian, Yanyu Huang, Pan Gao and Tianfeng Chen
摘要
A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.
原文链接
https://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc04021d