期刊
Angewandte Chemie International Edition
标题
A Giant Heterometallic Polyoxometalate Nanocluster for Enhanced Brain-Targeted Glioma Therapy
作者
Nizi Song, Mengya Lu, Dr. Jiancai Liu, Ming Lin, Ping Shangguan, Dr. Jiefei Wang, Dr. Bingyang Shi, Prof. Dr. Junwei Zhao
摘要
Giant heterometallic polyoxometalate (POM) clusters own flexibly adjustable active sites and are promising functional drug carriers. In their Research Article (e202319700), Jiefei Wang, Bingyang Shi, Junwei Zhao et al. designed the largest (3.0 nm × 6.0 nm) Ce3+/Ag+ co-encapsulated POM cluster with blood brain barrier-traversing and mitochondrial targeting properties to solve the long-standing brain delivery problem of drugs for glioma. As the first brain-targeting POM drug, Ag+ specifically activates reactive oxygen species regulated apoptosis pathway of glioma and efficiently prolongs the survival of orthotopic glioma-bearing mice.
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