Inside Cover: Polyspermine Imidazole-4,5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA

产品简述

期刊

Angewandte Chemie 


标题

Inside Cover: Polyspermine Imidazole-4,5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA (Angew. Chem. Int. Ed. 32/2012) (page 7864)


作者

Shiyue Duan, Weien Yuan, Fei Wu and Tuo Jin


摘要

Unlocking the endosome allows the release of siRNAs into the cytoplasm following the cellular uptake of nanoparticles made up of siRNAs and polyspermine imidazole-4,5-imine. In their Communication on page 7938 ff., T. Jin and co-workers show that a polymer of spermine with a pH-sensitive linkage degrades, upon entry into the endosome, into spermine and a nontoxic metabolite. Assays in cells and mice showed effective gene silencing by the polymer-packaged siRNAs without cytotoxicity.


原文链接

http://onlinelibrary.wiley.com/doi/10.1002/anie.v51.32/issuetoc



2017年01月10日

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