Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

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期刊

Biomaterials Science


标题

Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy


作者

Chao Huang, Chengchao Chu, Xiaoyong Wang, Huirong Lin, Junqing Wang, Yun Zeng, Wenzhen Zhu, Yi-Xiang J. Wang and Gang Liu


摘要

In this work, a potent photosensitizer, sinoporphyrin sodium (DVDMS), was loaded into RGD-modified ferritin (R-Fn) nanocages by a rapid, scalable and versatile approach for imaging guided photodynamic and photothermal (PTT/PDT) co-therapy. The resulting nanocomposite formed a well-defined nanocage with a photosensitizer loading capacity as high as 66.67 wt%, which far exceeds those reported previously. The bioengineered protein nanocage-based nanotheranostics exhibits a remarkably improved tumor treatment effect over DVDMS with good biocompatibility and the potential of clinical translation.


原文链接

http://pubs.rsc.org/en/content/articlelanding/2017/bm/c7bm00302a#!divAbstract

2017年08月09日

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