Thermoplasmonics: Molecular Hyperthermia: Spatiotemporal Protein Unfolding and Inactivation by Nanosecond Plasmonic Heating

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标题

Thermoplasmonics: Molecular Hyperthermia: Spatiotemporal Protein Unfolding and Inactivation by Nanosecond Plasmonic Heating


作者

Peiyuan Kang, Zhuo Chen, Steven O. Nielsen, Kenneth Hoyt, Sheena D'Arcy, Jeremiah J. Gassensmith, Zhenpeng Qin


摘要

In article number 1700841, Zhenpeng Qin and co-workers develop a novel method to create highly specific therapies by inactivating dysfunctional protein molecules. The approach inactivates protein molecules of interest by using short laser pulses and nanoparticles. This is achieved by nanosecond plasmonic heating of gold nanoparticles which creates an ultrahigh and ultrashort temperature increase, leading to selective inactivation and unfolding of proteins adjacent to the nanoparticle.


原文链接

http://onlinelibrary.wiley.com/doi/10.1002/smll.201770192/full


2017年09月28日

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