Stereoselective synthesis of sulfonated 1-indenones via radical-triggered multi-component cyclization of β-alkynyl propenones

产品简述

期刊

Chemical Communications


标题

Stereoselective synthesis of sulfonated 1-indenones via radical-triggered multi-component cyclization of β-alkynyl propenones


作者

Zheng-Jia Shen, Ya-Nan Wu, Chun-Lan He, Long He, Wen-Juan Hao, Ai-Fang Wang, Shu-Jiang Tu, Bo Jiang


摘要

New radical-triggered multi-component cyclizations of β-alkynyl propenones have been developed, leading to 50 examples of sulfonated 1-indenones with generally good yields and high levels of stereoselectivity. The oxidant-free azosulfonylation of β-alkynyl propenones with aryldiazonium salts and DABSO was realized under the neutral–redox conditions where TBHP enabled the direct selenosulfonylation of β-alkynyl propenones by combining sulfinic acids and diphenyl diselenide. This protocol features a broad substrate scope, high functional group tolerance and mild reaction conditions.


原文链接

http://pubs.rsc.org/en/content/articlelanding/2018/cc/c7cc08516h#!divAbstract


2018年01月26日

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