NHC-catalyzed [4+2] cycloaddition reactions for the synthesis of 3′-spirocyclic oxindoles via a C–F bond cleavage protocol

产品简述

期刊

Chemcomm


标题

NHC-catalyzed [4+2] cycloaddition reactions for the synthesis of 3′-spirocyclic oxindoles via a C–F bond cleavage protocol


作者

Jun Yan, Kuangxi Shi, Chengtao Zhao, Liyuan Ding, Shengsheng Jiang, Limin Yang, Guofu Zhong


摘要

A chiral NHC-catalyzed cycloaddition of γ-fluoroenals is developed. The nucleophilic γ-carbon generated via C–F bond cleavage undergoes highly enantioselective cycloaddition (up to >99% ee) to isatins and provides 3′-spirocyclic oxindoles in good yields (up to 91%).


原文链接

http://pubs.rsc.org/en/content/articlelanding/2018/cc/c7cc08048d#!divAbstract


2018年03月12日

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